As a stigmatized, painful disease that disproportionately affects women, migraine has significant negative consequences for individuals, their families, and society as a whole. Migraine is three times more common in women, reaching peak prevalence between 30 and 39 years of age, at a time when many women are rapidly growing in their career and balancing work, family, and social obligations. As a result, women account for a large majority of the estimated $78 billion in migraine-associated economic costs in the United States,1 representing about 80% of both direct medical costs and lost labor costs.